At around 6AM on the morning of August 28, 1854, the Lewis infant started vomiting and excreting greenish stools with a pungent smell. Her mother gathered the soils in a bucket of tepid water and tossed them into the cesspool in the family cellar. So began the story of London’s most horrific epidemic, the Broad Street cholera outbreak. In The Ghost Map: The Story of London’s Most Terrifying Epidemic — and How It Changed Science, Cities, and the Modern World, Steven Johnson, easily my favorite nonfiction writer working today, unleashes his signature cross-disciplinary thinking to explore the intricate interconnections between the spread of the disease, the rise of cities, the mysteries of medicine, and the very nature of scientific inquiry.

It’s the story of two men, Dr. John Snow and Rev. Henry Whitehead, who began to suspect the true cause of the outbreak and were eventually proven right by a rigorous, contested investigation. But Johnson’s genius is in his ability to translate the fascinating but seemingly irrelevant into a highly context of excruciating relevance, exploring what this story means for the liabilities and vulnerabilities of modern cities. (Cue in Monday’s omnibus of 7 essential books on cities)

This is a story with four protagonists: a deadly bacterium, a vast city, and two gifted but very different men. One dark week a hundred fifty years ago, in the midst of great terror and human suffering, their lives collided on London’s Broad Street, on the western edge of Soho.

This book is an attempt to tell the story in a way that does justice to the multiple scales of existence that helped bring it about: from the invisible kingdom of microscopic bacteria, to the tragedy and courage and camaraderie of individual lives, to the cultural realm of ideas and ideologies, all the way up to the sprawling metropolis of London itself. It’s the story of a map that lies at the intersection of all those different vectors, a map created to help make sense of an experience that defied human understanding.”

I’m a big believer in the power of maps as great sense-making mechanisms, so I find The Ghost Map deeply fascinating and an extraordinary feat of intelligence. It also makes me wonder how an epidemic of this scale would unfold today, at a time when evolved high-tech mapping tools like Ushahidi would not only glean better understanding of how the deadly wave is propagating but also track its progress in real-time and offer a powerful weapon in the arsenal of man’s epic battle against microbe.